Esophageal cancer commonly presents with progressive dysphagia, first to solids, then to soft food, eventually to liquids. By the time dysphagia is constant, the tumour is usually locally advanced. Workup includes endoscopy with biopsy, contrast CT, PET-CT, and endoscopic ultrasound for staging. Most thoracic squamous cell tumours benefit from neoadjuvant chemoradiotherapy (CROSS regimen) followed by esophagectomy. Lower-third adenocarcinomas may receive perioperative chemotherapy (FLOT) instead.