Colorectal cancer is increasingly seen in younger patients in India. Screening with colonoscopy from age 45-50 (earlier with risk factors) detects pre-cancerous polyps before they become cancer. Once cancer is established, treatment is staged: early colon cancer is treated with surgery alone; locally advanced rectal cancer typically receives neoadjuvant chemoradiotherapy followed by surgery; metastatic disease is managed multidisciplinary with chemotherapy and selective surgery.